QuickView for SRD5A2 (gene)

Gene Symbol:

SRD5A2 Homo sapiens

Full name:

steroid 5 alpha-reductase 2

Synonyms:

3-oxo-5-alpha-steroid 4-dehydrogenase 2, 5 alpha-SR2, S5AR 2, SR type 2, steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2), type II 5-alpha reductase

Genomic Location:

Chr 2: 31603160-31659544

Description:

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SRF_Q6 ,  GGGCGGR_SP1_Q6 ,  SRF_Q4 ,  SRF_Q5_01 ,  RYTAAWNNNTGAY_UNKNOWN ,  SRF_C

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-214

Cytogenetic Map:

2p23.1

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