QuickView for STIM1 (gene)

Gene Symbol:

STIM1 Homo sapiens

Full name:

stromal interaction molecule 1

Synonyms:

D11S4896E, GOK, IMD10, STRMK, TAM, TAM1, stromal interaction molecule 1

Genomic Location:

Chr 11: 3833509-4071015

Description:

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with t...

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This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  GATTGGY_NFY_Q6_01 ,  DR3_Q4 ,  MYOD_01 ,  RYTTCCTG_ETS2_B ,  YGTCCTTGR_UNKNOWN ,  GCANCTGNY_MYOD_Q6 ,  AACTGAC_MIR223 ,  CIZ_01 ,  ATF4_Q2 ,  TGACCTY_ERR1_Q2 ,  TATAAA_TATA_01 ,  AR_01 ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  ACTGCCT_MIR34B ,  TGCCAAR_NF1_Q6 ,  AP4_Q6_01 ,  MYOGENIN_Q6 ,  SCGGAAGY_ELK1_02 ,  T3R_Q6 ,  CAGCTG_AP4_Q5 ,  ZF5_B ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  ELF1_Q6 ,  AAGTCCA_MIR422B_MIR422A ,  LBP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-378* ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

11p15.4

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