QuickView for Sp3 (gene)

Gene Symbol:

SP3 Homo sapiens

Full name:

Sp3 transcription factor

Synonyms:

SPR2, transcription factor Sp3, GC-binding transcription factor Sp3, specificity protein 3

Genomic Location:

Chr 2: 174481504-174538309

Description:

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription fac...

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This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PBX1_02 ,  GTATTAT_MIR3693P ,  SMTTTTGT_UNKNOWN ,  CEBPA_01 ,  GATA1_01 ,  AAGCCAT_MIR135A_MIR135B ,  GCATTTG_MIR105 ,  RYTTCCTG_ETS2_B ,  NFAT_Q6 ,  YTATTTTNR_MEF2_02 ,  E2F4DP1_01 ,  AACTGAC_MIR223 ,  EVI1_04 ,  TTTGTAG_MIR520D ,  ATGTACA_MIR493 ,  GTGCAAA_MIR507 ,  AP2ALPHA_01 ,  MAF_Q6 ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  AGCATTA_MIR155 ,  TGTATGA_MIR4853P ,  TGCAAAC_MIR452 ,  E2F_Q6 ,  ETS2_B ,  SP3_Q3 ,  E2F_Q4 ,  TGCCTTA_MIR124A ,  ATTCTTT_MIR186 ,  GTAAGAT_MIR200A ,  GCAAAAA_MIR129 ,  GGGCGGR_SP1_Q6 ,  GTATGAT_MIR154_MIR487 ,  E2F1DP2_01 ,  LMO2COM_02 ,  CCCNNGGGAR_OLF1_01 ,  GCGNNANTTCC_UNKNOWN ,  ACTGAAA_MIR30A3P_MIR30E3P ,  GATA2_01 ,  E2F1DP1_01 ,  TTGCCAA_MIR182 ,  AP2_Q6 ,  ELK1_01 ,  ATATGCA_MIR448 ,  E2F1DP1RB_01 ,  E2F_02 ,  GTTATAT_MIR410 ,  KMCATNNWGGA_UNKNOWN ,  E2F1_Q3 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  TCCATTKW_UNKNOWN ,  E2F4DP2_01 ,  TAANNYSGCG_UNKNOWN ,  SMAD_Q6 ,  GCTNWTTGK_UNKNOWN ,  CGTCTTA_MIR208 ,  TATTATA_MIR374 ,  SP1_Q2_01 ,  E2F1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-363 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-493-5p ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-543

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miRNA binding sites
(Source: miRecords):

[miR-27a] Targeted Genes

Cytogenetic Map:

2q31.1

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