QuickView for Stromal interaction molecule (biogroup)

Description:: STIM proteins contain a single SAM (sterile alpha-motif) domain and an unpaired EF hand within the highly conserved extracellular region, and the coiled-coil domains that are conserved in structure and position within the cytoplasmic region. The EF-hand and SAM domain of the STIM proteins serves as a Ca2+ sensory region. "Hidden" EF hand and SAM domains have a stable intramolecular association. Destabilization of the EF-SAM association during Ca2+ depletion leads to partial unfolding and aggregation (homooligomerization). STIM oligomerization is a key induction step in the activation of Ca(2+)-permeable channels on the plasma membrane. In human cells, STIM1 and STIM2 are regulators of store-operated calcium (Ca(2+)) entry as well as basal cytoplasmic Ca(2+) levels.

2 features

Symbol	EntrezGene ID
STIM2	57620
STIM1	6786