Name: | Sulfadiazine |
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PubChem Compound ID: | 5215 |
Description: | One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. |
Molecular formula: | C10H10N4O2S |
Molecular weight: | 250.278 g/mol |
Synonyms: |
Piridisir; Sulfanilamide, N(sup 1)-2-pyrimidinyl-, N(sup 1)-sodium deriv; Pecta-diazine, suspension; Sulfadiazine (TN); Neotrizine; 68-35-9; S. N. 112; Cremodiazine; Diazyl (VAN); NSC 35600.
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Name: | Sulfadiazine |
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Name (isomeric): | DB00359 |
Drug Type: | small molecule |
Description: | One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. |
Synonyms: |
Sulphadiazine; SDA; Sulfapyrimidine; Sulfadiazene; Sulfapirimidin; Sulfanilamidopyrimidine; Sulfapyrimidin; Sulfadiazin
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Brand: | Lipo-Diazine, Adiazine, Cocodiazine, Trisem, Cremotres, Codiazine, Palatrize, Triple Sulfas, Sulfonamides Duplex, Sulfose, Diazolone, Metha-Meridiazine, Pyrimal, Sanodiazine, Triple Sulfoid, Pecta-Diazine, Diazyl, Sulfa-Triple #2, Sulfolex, Neotrizine, Quadetts, Lipo-Levazine, Deltazina, Terfonyl, Sulfatryl, Coco-Diazine, Sulfonsol, Spofadrizine, Neazine, Sterazine, Tri-Sulfameth, Trifonamide, Debenal, Piridisir, Sulfacombin, Diazovit, Liquadiazine, Truozine, Lantrisul, Theradiazine, Adiazin, Sulfaloid, Triple Sulfa, Honey Diazine, Pirimal, Cremodiazine, Diazin, Eskadiazine, Quadramoid, Microsulfon, Sulfazine |
Category: | Anti-Infective Agents, Antiprotozoal Agents, Antiprotozoals, Coccidiostats, Anti-Infectives |
CAS number: | 68-35-9 |
Indication: | For the treatment of rheumatic fever and meningococcal meningitis |
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Pharmacology: |
Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobe...
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Mechanism of Action: | Sulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. |
Route of elimination: | Sulfadiazine is excreted largely in the urine. |
Toxicity: | Oral LD50 in mouse is 1500 mg/kg. |
Affected organisms: | Enteric bacteria and other eubacteria |
Drug interaction: |
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