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QuickView for Sulfadiazine (compound)


PubChem
Name: Sulfadiazine
PubChem Compound ID: 5215
Description: One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Molecular formula: C10H10N4O2S
Molecular weight: 250.278 g/mol
Synonyms:
Piridisir; Sulfanilamide, N(sup 1)-2-pyrimidinyl-, N(sup 1)-sodium deriv; Pecta-diazine, suspension; Sulfadiazine (TN); Neotrizine; 68-35-9; S. N. 112; Cremodiazine; Diazyl (VAN); NSC 35600.
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DrugBank
Identification
Name: Sulfadiazine
Name (isomeric): DB00359
Drug Type: small molecule
Description: One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Synonyms:
Sulphadiazine; SDA; Sulfapyrimidine; Sulfadiazene; Sulfapirimidin; Sulfanilamidopyrimidine; Sulfapyrimidin; Sulfadiazin
Brand: Lipo-Diazine, Adiazine, Cocodiazine, Trisem, Cremotres, Codiazine, Palatrize, Triple Sulfas, Sulfonamides Duplex, Sulfose, Diazolone, Metha-Meridiazine, Pyrimal, Sanodiazine, Triple Sulfoid, Pecta-Diazine, Diazyl, Sulfa-Triple #2, Sulfolex, Neotrizine, Quadetts, Lipo-Levazine, Deltazina, Terfonyl, Sulfatryl, Coco-Diazine, Sulfonsol, Spofadrizine, Neazine, Sterazine, Tri-Sulfameth, Trifonamide, Debenal, Piridisir, Sulfacombin, Diazovit, Liquadiazine, Truozine, Lantrisul, Theradiazine, Adiazin, Sulfaloid, Triple Sulfa, Honey Diazine, Pirimal, Cremodiazine, Diazin, Eskadiazine, Quadramoid, Microsulfon, Sulfazine
Category: Anti-Infective Agents, Antiprotozoal Agents, Antiprotozoals, Coccidiostats, Anti-Infectives
CAS number: 68-35-9
Pharmacology
Indication: For the treatment of rheumatic fever and meningococcal meningitis
Pharmacology:
Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobe...
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Mechanism of Action: Sulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Route of elimination: Sulfadiazine is excreted largely in the urine.
Toxicity: Oral LD50 in mouse is 1500 mg/kg.
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Drug interaction:
TorasemideSulfadiazine, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Sulfadiazine is initiated, discontinued or dose changed.
Methenamine mandelatePossible crystallization of urates with this combination
CyclosporineThe sulfonamide decreases the effect of cyclosporine
PhenytoinThe sulfonamide increases the effect of hydantoin
FosphenytoinThe sulfonamide increases the effect of hydantoin
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