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QuickView for Sulfapyridine (compound)


PubChem
Name: Sulfapyridine
PubChem Compound ID: 5336
Description: Antibacterial, potentially toxic, used to treat certain skin diseases.
Molecular formula: C11H11N3O2S
Molecular weight: 249.29 g/mol
Synonyms:
2-Sulfapyridine; Prestwick1_000762; Dagenan; Piridazol; NCGC00016408-01; Spectrum2_001323; Spectrum3_001773; SPBio_002743; 144-83-2; Haptocil.
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DrugBank
Identification
Name: Sulfapyridine
Name (isomeric): DB00891
Drug Type: small molecule
Description: Antibacterial, potentially toxic, used to treat certain skin diseases.
Synonyms:
2-Sulfapyridine; N-2-Pyridylsulfanilamide; N(sup 1)-2-Pyridylsulfanilamide; 4-[(2-Pyridylamino)sulfonyl]aniline; Sulphapyridine; 2-Sulfanilylaminopyridine; N1-2-Pyridylsulfanilamide; N(sup1)-Pyridylsulfanilamide; 4-(2-Pyridinylsulfonyl)aniline; 2-Sulfanilamidopyridine.
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Brand: Sulfidine, Pyriamid, Relbapiridina, Ronin, Coccoclase, Eubasin, Eubasinum, Dagenan, M and B 693, Piridazol, Streptosilpyridine, Adiplon, Plurazol, Thioseptal, Sulfidin, Pyridazol, Trianon, Septipulmon, Haptocil
Brand name mixture: Trisulfa G Liq(Sulfamethazine + Sulfapyridine + Sulfathiazole), Neutral Sulfa 50(Sulfamethazine + Sulfapyridine + Sulfathiazole), Foot Rot Boluses(Ethylenediamine Dihydroiodide + Sulfapyridine), Neutral Sulfa 7(Sulfamethazine + Sulfapyridine + Sulfathiazole)
Category: Anti-Infective Agents, Dermatitis herpetiformis suppressant, Sulfonamides, Dermatologic Agents, Anti-Infectives
CAS number: 144-83-2
Pharmacology
Indication: For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum
Pharmacology:
Sulfapyridine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminob...
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Mechanism of Action:
Sulfapyridine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid by means of processing the substrate para-aminobenzoic acid (PABA). Dihydropteroate synthetase activity is vital in the synthesis of folate, and folate is required for ce...
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Absorption: Approximately 60-80%
Protein binding: Approximately 50% bound to plasma proteins.
Biotransformation: Hepatic.
Half Life: 6-14 hours.
Toxicity: LD50 is 15800 mg/kg (orally in rats).
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
ChlorpropamideSulfonamide/sulfonylurea: possible hypoglycemia
MethotrexateThe sulfamide increases the toxicity of methotrexate

Targets


Enzymes