Name: | Sulfapyridine |
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PubChem Compound ID: | 5336 |
Description: | Antibacterial, potentially toxic, used to treat certain skin diseases. |
Molecular formula: | C11H11N3O2S |
Molecular weight: | 249.29 g/mol |
Synonyms: |
2-Sulfapyridine; Prestwick1_000762; Dagenan; Piridazol; NCGC00016408-01; Spectrum2_001323; Spectrum3_001773; SPBio_002743; 144-83-2; Haptocil.
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Name: | Sulfapyridine |
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Name (isomeric): | DB00891 |
Drug Type: | small molecule |
Description: | Antibacterial, potentially toxic, used to treat certain skin diseases. |
Synonyms: |
2-Sulfapyridine; N-2-Pyridylsulfanilamide; N(sup 1)-2-Pyridylsulfanilamide; 4-[(2-Pyridylamino)sulfonyl]aniline; Sulphapyridine; 2-Sulfanilylaminopyridine; N1-2-Pyridylsulfanilamide; N(sup1)-Pyridylsulfanilamide; 4-(2-Pyridinylsulfonyl)aniline; 2-Sulfanilamidopyridine.
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Brand: | Sulfidine, Pyriamid, Relbapiridina, Ronin, Coccoclase, Eubasin, Eubasinum, Dagenan, M and B 693, Piridazol, Streptosilpyridine, Adiplon, Plurazol, Thioseptal, Sulfidin, Pyridazol, Trianon, Septipulmon, Haptocil |
Brand name mixture: | Trisulfa G Liq(Sulfamethazine + Sulfapyridine + Sulfathiazole), Neutral Sulfa 50(Sulfamethazine + Sulfapyridine + Sulfathiazole), Foot Rot Boluses(Ethylenediamine Dihydroiodide + Sulfapyridine), Neutral Sulfa 7(Sulfamethazine + Sulfapyridine + Sulfathiazole) |
Category: | Anti-Infective Agents, Dermatitis herpetiformis suppressant, Sulfonamides, Dermatologic Agents, Anti-Infectives |
CAS number: | 144-83-2 |
Indication: | For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum |
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Pharmacology: |
Sulfapyridine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminob...
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Mechanism of Action: |
Sulfapyridine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid by means of processing the substrate para-aminobenzoic acid (PABA). Dihydropteroate synthetase activity is vital in the synthesis of folate, and folate is required for ce...
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Absorption: | Approximately 60-80% |
Protein binding: | Approximately 50% bound to plasma proteins. |
Biotransformation: | Hepatic. |
Half Life: | 6-14 hours. |
Toxicity: | LD50 is 15800 mg/kg (orally in rats). |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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