QuickView for TAPBP;jsessionid=AD9CFCA5EA91922DBF0DAD75CE004FF1 (gene)

Gene Symbol:

TAPBP Homo sapiens

Full name:

TAP binding protein

Synonyms:

NGS17, TAPA, TPN, TPSN, tapasin, NGS-17, TAP binding protein (tapasin), TAP-associated protein

Genomic Location:

Chr 6: 33375449-33389967

Description:

This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential fo...

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This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  TTANTCA_UNKNOWN ,  POU3F2_01 ,  HP1SITEFACTOR_Q6 ,  FAC1_01 ,  IRF1_Q6 ,  PBX1_01 ,  DBP_Q6 ,  PITX2_Q2 ,  IRF_Q6 ,  TGTTTGY_HNF3_Q6 ,  CAGTCAC_MIR134 ,  POU3F2_02 ,  IRF7_01 ,  ICSBP_Q6 ,  ISRE_01 ,  STTTCRNTTT_IRF_Q6 ,  IRF2_01

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Cytogenetic Map:

6p21.32

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