QuickView for TCF7L1 (gene)
- Gene Symbol:
- TCF7L1
Homo sapiens - Full name:
- transcription factor 7 like 1
- Synonyms:
- TCF-3, TCF3, transcription factor 7-like 1, HMG box transcription factor 3, transcription factor 7-like 1 (T-cell specific, HMG-box)
- Genomic Location:
- Chr 2: 85214245-85391016
- Description:
-
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
2p11.2
GO Molecular Function
sequence-specific DNA binding | beta-catenin binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nucleic acid binding | chromatin binding | DNA binding | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cellular process | chromatin organization | canonical Wnt signaling pathway | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | cellular nitrogen compound biosynthetic process | beta-catenin-TCF complex assembly | cellular nitrogen compound metabolic process | cellular component assembly | cellular biosynthetic process | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of signal transduction | Wnt signaling pathway | regulation of gene expression | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | cell communication | regulation of cellular metabolic process | regulation of RNA metabolic process | protein-containing complex assembly | DNA-binding transcription factor activity | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | regulation of Wnt signaling pathway | transcription, DNA-templated | regulation of cell communication | signaling | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | organelle organization | heterocycle metabolic process | chromosome organization | cellular metabolic process | signal transduction | regulation of signaling | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
