QuickView for TDP1 (gene)

Gene Symbol:

TDP1 Homo sapiens

Full name:

tyrosyl-DNA phosphodiesterase 1

Synonyms:

tyrosyl-DNA phosphodiesterase 1, tyr-DNA phosphodiesterase 1

Genomic Location:

Chr 14: 89491999-89580861

Description:

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a ro...

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The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RCGCANGCGY_NRF1_Q6 ,  AACTTT_UNKNOWN

miRNA binding sites
(Source: miRecords):

hsa-miR-1 Targeted Genes

Cytogenetic Map:

14q32.11

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