QuickView for TFAM (gene)
- Gene Symbol:
- TFAM
Homo sapiens - Full name:
- transcription factor A, mitochondrial
- Synonyms:
- MTDPS15, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3, transcription factor A, mitochondrial, mitochondrial transcription factor 1, mitochondrial transcription factor A, transcription factor 6, transcription factor 6-like 1, transcription factor 6-like 2 (mitochondrial transcription factor), transcription factor 6-like 3
- Genomic Location:
- Chr 10: 59815182-59825903
- Description:
-
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternati...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
10q21.1
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | nucleic acid binding | transcription coactivator binding | chromatin binding | DNA binding | organic cyclic compound binding | mitochondrial promoter sequence-specific DNA binding | DNA binding, bending | protein binding | DNA-binding transcription factor activity | transcription factor binding | mitochondrial sequence-specific DNA-binding transcription factor activity | transcription cofactor binding | heat shock protein binding | heterocyclic compound binding | RNA binding
GO Biological Process
RNA metabolic process | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | positive regulation of cellular biosynthetic process | cellular process | mitochondrial transcription | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | mitochondrial respiratory chain complex assembly | cellular aromatic compound metabolic process | cellular component organization | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | cellular biosynthetic process | mitochondrion organization | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | biosynthetic process | aromatic compound biosynthetic process | cellular protein-containing complex assembly | transcription initiation from mitochondrial promoter | regulation of cellular metabolic process | regulation of RNA metabolic process | protein-containing complex assembly | DNA-binding transcription factor activity | metabolic process | mitochondrial gene expression | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | mitochondrial sequence-specific DNA-binding transcription factor activity | organelle organization | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | mitochondrial RNA metabolic process | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
mitochondrial matrix | intracellular membrane-bounded organelle | cell | mitochondrial nucleoid | cytoplasm | nucleoid | intracellular organelle | protein-containing complex | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
