QuickView for TGC (gene)

Gene Symbol:

TGM2 Homo sapiens

Full name:

transglutaminase 2

Synonyms:

TG(C), TGC, protein-glutamine gamma-glutamyltransferase 2, C polypeptide, protein-glutamine-gamma-glutamyltransferase, TGase C, TGase H, TGase-2, tissue transglutaminase, transglutaminase C, transglutaminase H

Genomic Location:

Chr 20: 36190277-36227114

Description:

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, i...

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Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Cytogenetic Map:

20q11.23

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