QuickView for TLR5 (gene)

Gene Symbol:

TLR5 Homo sapiens

Full name:

toll like receptor 5

Synonyms:

MELIOS, SLE1, SLEB1, TIL3, toll-like receptor 5, systemic lupus erythematosus susceptibility 1, toll/interleukin-1 receptor-like protein 3

Genomic Location:

Chr 1: 221350207-221383247

Description:

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the p...

View Full Description

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Cytogenetic Map:

1q41

search → result