QuickView for TMEM173 (gene)

Gene Symbol:

TMEM173 Homo sapiens

Full name:

transmembrane protein 173

Synonyms:

ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING, stimulator of interferon genes protein, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, endoplasmic reticulum IFN stimulator, endoplasmic reticulum interferon stimulator, mitochondrial mediator of IRF3 activation

Genomic Location:

Chr 5: 138835733-138842476

Description:

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to pla...

View Full Description

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Cytogenetic Map:

5q31.2

search → result