QuickView for TNK2 (gene)

Gene Symbol:

TNK2 Homo sapiens

Full name:

tyrosine kinase non receptor 2

Synonyms:

ACK, ACK-1, ACK1, p21cdc42Hs, activated CDC42 kinase 1, activated Cdc42-associated kinase 1, activated p21cdc42Hs kinase, tyrosine kinase non-receptor protein 2

Genomic Location:

Chr 3: 197074633-197120277

Description:

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the G...

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This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA_Q6 ,  GGGACCA_MIR133A_MIR133B ,  GATAAGR_GATA_C ,  LMO2COM_02 ,  GATA6_01 ,  GATA1_02 ,  AATGTGA_MIR23A_MIR23B ,  SCGGAAGY_ELK1_02 ,  TCCAGAG_MIR518C

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-7

Cytogenetic Map:

3q29

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