QuickView for TRPM2 (gene)

Gene Symbol:

TRPM2 Homo sapiens

Full name:

transient receptor potential cation channel subfamily M member 2

Synonyms:

EREG1, KNP3, LTRPC2, LTrpC-2, NUDT9H, NUDT9L1, TRPC7, transient receptor potential cation channel subfamily M member 2, estrogen-responsive element-associated gene 1 protein, long transient receptor potential channel 2, transient receptor potential channel 7, transient receptor potential melastatin 2

Genomic Location:

Chr 21: 44597912-44687392

Description:

The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protei...

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The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGGCCC_MIR296 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  CCTGCTG_MIR214 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ATGAAGG_MIR205

Cytogenetic Map:

21q22.3

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