QuickView for UBE2D3;jsessionid=9C6D18FC6B227F664420F46E1318488C (gene)

Gene Symbol:

UBE2D3 Homo sapiens

Full name:

ubiquitin conjugating enzyme E2 D3

Synonyms:

E2(17)KB3, UBC4/5, UBCH5C, ubiquitin-conjugating enzyme E2 D3, (E3-independent) E2 ubiquitin-conjugating enzyme D3, E2 ubiquitin-conjugating enzyme D3, ubiquitin carrier protein D3, ubiquitin conjugating enzyme E2D 3, ubiquitin-conjugating enzyme E2(17)KB 3, ubiquitin-conjugating enzyme E2-17 kDa 3, ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5), ubiquitin-protein ligase D3

Genomic Location:

Chr 4: 103936217-104009473

Description:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of th...

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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  SP1_01 ,  NFMUE1_Q6 ,  GTATTAT_MIR3693P ,  ATAAGCT_MIR21 ,  GTGTTGA_MIR505 ,  STAT4_01 ,  PU1_Q6 ,  MYOD_01 ,  HEN1_01 ,  SRF_Q6 ,  GCANCTGNY_MYOD_Q6 ,  TMTCGCGANR_UNKNOWN ,  GTGACTT_MIR224 ,  ATCMNTCCGY_UNKNOWN ,  GTACTGT_MIR101 ,  NFKAPPAB_01 ,  TAGCTTT_MIR9 ,  CTTTGA_LEF1_Q2 ,  MYCMAX_B ,  TGACCTY_ERR1_Q2 ,  E2F1_Q4 ,  HEB_Q6 ,  NFKAPPAB65_01 ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  AR_Q6 ,  AGCATTA_MIR155 ,  TITF1_Q3 ,  CAGGTA_AREB6_01 ,  GTGACGY_E4F1_Q6 ,  CAGGTG_E12_Q6 ,  CAGCTTT_MIR320 ,  CREB_02 ,  GGGCGGR_SP1_Q6 ,  OCT1_03 ,  AAGWWRNYGGC_UNKNOWN ,  MGGAAGTG_GABP_B ,  AGGTGCA_MIR500 ,  E47_01 ,  GCM_Q2 ,  GCCNNNWTAAR_UNKNOWN ,  NF1_Q6_01 ,  ATACTGT_MIR144 ,  AATGTGA_MIR23A_MIR23B ,  HAND1E47_01 ,  ELK1_01 ,  AP4_Q6_01 ,  HEN1_02 ,  PAX5_01 ,  COUP_DR1_Q6 ,  ATAACCT_MIR154 ,  CREL_01 ,  RCGCANGCGY_NRF1_Q6 ,  NFKB_Q6_01 ,  TAANNYSGCG_UNKNOWN ,  YRCCAKNNGNCGC_UNKNOWN ,  CAGCTG_AP4_Q5 ,  AP4_Q5 ,  DR4_Q2 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-421 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-500 ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-544

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Cytogenetic Map:

4q24

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