QuickView for UBE2L3 (gene)

Gene Symbol:

UBE2L3 Homo sapiens

Full name:

ubiquitin conjugating enzyme E2 L3

Synonyms:

E2-F1, L-UBC, UBCH7, UbcM4, ubiquitin-conjugating enzyme E2 L3, E2 ubiquitin-conjugating enzyme L3, ubiquitin carrier protein L3, ubiquitin conjugating enzyme E2L 3, ubiquitin-conjugating enzyme E2-F1, ubiquitin-conjugating enzyme UBCH7, ubiquitin-protein ligase L3

Genomic Location:

Chr 22: 20251957-20308323

Description:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ub...

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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ETS_Q4 ,  RYTTCCTG_ETS2_B ,  EFC_Q6 ,  TGTGTGA_MIR377 ,  TTTGTAG_MIR520D ,  RYCACNNRNNRNCAG_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  CTCAGGG_MIR125B_MIR125A ,  GGGCGGR_SP1_Q6 ,  NERF_Q2 ,  MGGAAGTG_GABP_B ,  AP2_Q3 ,  NRF2_Q4 ,  CTGCAGY_UNKNOWN ,  RORA2_01 ,  GGTAACC_MIR4095P ,  ELK1_02 ,  AACTTT_UNKNOWN ,  ETS1_B ,  ACCATTT_MIR522 ,  AGGAAGC_MIR5163P

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-409-5p ,  Predicted Gene Targets for miR-544

Cytogenetic Map:

22q11.21

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