QuickView for UVRAG (gene)

Gene Symbol:

UVRAG Homo sapiens

Full name:

UV radiation resistance associated

Synonyms:

DHTX, VPS38, p63, UV radiation resistance-associated gene protein, beclin 1 binding protein, disrupted in heterotaxy

Genomic Location:

Chr 11: 75203860-75532930

Description:

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with lef...

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This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  PR_02 ,  TGANTCA_AP1_C ,  TCANNTGAY_SREBP1_01 ,  MYC_Q2 ,  CACGTG_MYC_Q2 ,  MYCMAX_02 ,  NFY_Q6_01 ,  ALPHACP1_01 ,  RFX1_02 ,  CAGGTG_E12_Q6 ,  CTCAGGG_MIR125B_MIR125A ,  AR_03 ,  YGCANTGCR_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  S8_01 ,  MGGAAGTG_GABP_B ,  GTTGNYNNRGNAAC_UNKNOWN ,  CHOP_01 ,  SCGGAAGY_ELK1_02 ,  TGACAGNY_MEIS1_01 ,  USF2_Q6 ,  AACTTT_UNKNOWN ,  USF_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-539

Cytogenetic Map:

11q13.5

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