QuickView for VMP1;jsessionid=19463099041E70A62A2B56673EB9880A (gene)

Gene Symbol:

VMP1 Homo sapiens

Full name:

vacuole membrane protein 1

Synonyms:

EPG3, TANGO5, TMEM49, vacuole membrane protein 1, ectopic P-granules autophagy protein 3 homolog, transmembrane protein 49, transport and golgi organization 5 homolog

Genomic Location:

Chr 17: 55139811-55273235

Description:

This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degr...

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This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ACTTTAT_MIR1425P ,  GTGACGY_E4F1_Q6 ,  TTCYRGAA_UNKNOWN ,  TGCCTTA_MIR124A ,  GGGCGGR_SP1_Q6 ,  MGGAAGTG_GABP_B ,  AAAGACA_MIR511 ,  GCM_Q2 ,  CETS1P54_01 ,  SCGGAAGY_ELK1_02 ,  NRF2_01 ,  CCGNMNNTNACG_UNKNOWN ,  ELK1_02 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

Cytogenetic Map:

17q23.1

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