QuickView for ZNF408 (gene)
- Gene Symbol:
- ZNF408
Homo sapiens - Full name:
- zinc finger protein 408
- Synonyms:
- EVR6, RP72, zinc finger protein 408, PR domain zinc finger protein 17
- Genomic Location:
- Chr 11: 46678944-46684037
- Description:
-
The protein encoded by this gene contains ten tandem zinc fingers and an N-terminal SET domain, so it is likely a DNA binding protein that interacts with other proteins. In adults, the encoded protein is expressed most highly in retina. Consequently, defects in this gene have been associated with familial exudative vitreoretinopathy (FEVR) and reti...
- Orthologs:
- Mus musculus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio , Rattus norvegicus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
SRF_Q6 , CIZ_01 , TEL2_Q6 , GGGCGGR_SP1_Q6 , MGGAAGTG_GABP_B , RNGTGGGC_UNKNOWN , CETS1P54_01 , ELK1_01 , SCGGAAGY_ELK1_02 , NRF2_01
- Cytogenetic Map:
-
11p11.2
GO Molecular Function
RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | nucleic acid binding | DNA binding | identical protein binding | ion binding | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cellular process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | regulation of gene expression | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | regulation of RNA metabolic process | DNA-binding transcription factor activity | metabolic process | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | heterocycle metabolic process | cellular metabolic process | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular
