QuickView for angiopoietin 1 (gene)

Gene Symbol:

ANGPT1 Homo sapiens

Full name:

angiopoietin 1

Synonyms:

AGP1, AGPT, ANG1, angiopoietin-1, ANG-1

Genomic Location:

Chr 8: 108330886-108579430

Description:

This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activ...

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This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TFIIA_Q6 ,  TGANTCA_AP1_C ,  GATA1_01 ,  AAAGGGA_MIR204_MIR211 ,  TGANNYRGCA_TCF11MAFG_01 ,  GATA3_01 ,  TTGCWCAAY_CEBPB_02 ,  GCANCTGNY_MYOD_Q6 ,  CEBP_Q2_01 ,  IPF1_Q4 ,  LYF1_01 ,  COUP_01 ,  PBX1_01 ,  TGACCTY_ERR1_Q2 ,  COMP1_01 ,  GGGNRMNNYCAT_UNKNOWN ,  TATAAA_TATA_01 ,  AR_Q6 ,  CEBP_Q2 ,  NFE2_01 ,  TITF1_Q3 ,  CATGTAA_MIR496 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  AP1_01 ,  ETS2_B ,  LHX3_01 ,  TGCGCANK_UNKNOWN ,  NKX62_Q2 ,  TGCCTTA_MIR124A ,  NF1_Q6 ,  FOXJ2_01 ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  STAT5A_03 ,  CEBPB_02 ,  LMO2COM_02 ,  SOX5_01 ,  GATA1_02 ,  GATA2_01 ,  RORA1_01 ,  GFI1_01 ,  TTGTTT_FOXO4_01 ,  WGGAATGY_TEF1_Q6 ,  ATF1_Q6 ,  WTTGKCTG_UNKNOWN ,  RGAGGAARY_PU1_Q6 ,  RORA2_01 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  CDC5_01 ,  SRY_02 ,  BRN2_01 ,  TTANWNANTGGM_UNKNOWN ,  ERR1_Q2 ,  PAX4_01 ,  TCF11MAFG_01 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

8q23.1

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