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QuickView for bentiromide (compound)
PubChem
| Name: | bentiromide |
|---|---|
| PubChem Compound ID: | 2329 |
| Molecular formula: | C23H20N2O5 |
| Molecular weight: | 404.415 g/mol |
| Synonyms: |
Bentiromide (JAN/USAN); (S)-p-(alpha-Benzamido-p-hydroxyhydrocinnamamido)benzoic acid; (S)-4-((2-(Benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl)amino)benzoic acid; Chymex; PFD; Benzoic acid, 4-((2-(benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl)amino)-, (S)-; Benzoic acid, 4-[[2-(benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-, (S)-; D01346; Btpaba; 4-((2-(Benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl)amino)benzoic acid.
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DrugBank
Identification
| Name: | bentiromide |
|---|---|
| Name (isomeric): | DB00522 |
| Drug Type: | small molecule |
| Synonyms: |
BTPABA; Bentiromido [INN-Spanish]; Bentiromide [USAN:BAN:INN:JAN]; Bentiromidum [INN-Latin]; PFT; PFD
|
| Brand: | Chymex |
| Category: | Indicators and Reagents, Diagnostic aids |
| CAS number: | 37106-97-1 |
Pharmacology
| Indication: | Used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. |
|---|---|
| Pharmacology: |
Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of p-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pan...
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| Mechanism of Action: | Bentiromide is a peptide that is broken down in the pancreas by chymotrypsin. By determining the output of unchanged bentiromide in the urine following oral administration, it is possible to determine the sufficiency of pancreatic activity. |
| Biotransformation: | Primarily hepatic. Enzymatic activity capable of hydrolyzing bentiromide has also been found in normal small intestine. |
| Toxicity: | Symptoms of overdose include shortness of breath and troubled breathing. |
| Affected organisms: | Humans and other mammals |
Targets
