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QuickView for botulinum toxin type B (compound)

PubChem Substance
Name: rimabotulinumtoxinB
PubChem Substance ID: 3791687
Botulin B; NeuroBloc; Myobloc; Botulin toxin B; EINECS 297-255-5; Toxins, botulin, B; 93384-44-2
Name: rimabotulinumtoxinB
Name (isomeric): DB00042
Drug Type: biotech
BTX-B; Botulinum neurotoxin type B precursor
Brand: Neurobloc (Solstice Neurosciences), Myobloc (Solstice Neurosciences)
Category: Antidystonic Agents
CAS number: 93384-44-2
Indication: For the treatment of patients with cervical dystonia to reduce the severity of abnormal head position and neck pain associated with cervical dystonia.
Botulinum Toxin Type B inhibits acetylcholine release at the neuromuscular junction via a three stage process: 1) Heavy Chain mediated neurospecific binding of the toxin, 2) internalization of the toxin by receptor-mediated endocytosis, and 3) ATP and pH dependent translocation of the Light Chain to the neuronal cytosol where it acts as a zinc-depe...
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Mechanism of Action: Botulinum Toxin Type B binds to and cleaves the synaptic Vesicle Associated Membrane Protein (VAMP, also known as synaptobrevin) which is a component of the protein complex responsible for docking and fusion of the synaptic vesicle to the presynaptic membrane, a necessary step to neurotransmitter release.
Absorption: Though pharmacokinetic or ADME studies were not performed, Botulinum Toxin Type B is not expected to be present in the peripheral blood at measurable levels following IM injection at the recommended doses.
Toxicity: One unit of Botulinum Toxin Type B corresponds to the calculated median lethal intraperitoneal dose (LD50) in mice.
Affected organisms: Humans and other mammals