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QuickView for cmbl (gene)
- Gene Symbol:
- CMBL
Homo sapiens - Full name:
- carboxymethylenebutenolidase homolog
- Synonyms:
- JS-1, carboxymethylenebutenolidase homolog, carboxymethylenebutenolidase homolog (Pseudomonas), carboxymethylenebutenolidase-like (Pseudomonas)
- Genomic Location:
- Chr 5: 10330707-10361168
- Description:
-
CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).
- Orthologs:
- Mus musculus , Rattus norvegicus , Saccharomyces cerevisiae , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
5p15.2
GO Molecular Function
hydrolase activity | catalytic activity
GO Biological Process
cellular process | xenobiotic metabolic process | response to stimulus | cellular response to xenobiotic stimulus | response to xenobiotic stimulus | metabolic process | cellular metabolic process
GO Cellular Component
cell | cytoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | intracellular
