QuickView for cyp46a1 (gene)

Gene Symbol:

CYP46A1 Homo sapiens

Full name:

cytochrome P450 family 46 subfamily A member 1

Synonyms:

CP46, CYP46, cholesterol 24-hydroxylase, CH24H, cytochrome P450 46A1, cytochrome P450, family 46, subfamily A, polypeptide 1, cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)

Genomic Location:

Chr 14: 99220508-99263391

Description:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholest...

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGTTGA_MIR505 ,  TTANTCA_UNKNOWN ,  TTCNRGNNNNTTC_HSF_Q6 ,  EVI1_04 ,  MEF2_04 ,  RGAANNTTC_HSF1_01 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  TTCYRGAA_UNKNOWN ,  POU1F1_Q6 ,  HSF_Q6 ,  CART1_01 ,  CAGCTG_AP4_Q5 ,  SF1_Q6 ,  STAT5A_02 ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-505

Cytogenetic Map:

14q32.2

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