QuickView for desmoglein 2 (gene)

Gene Symbol:

DSG2 Homo sapiens

Full name:

desmoglein 2

Synonyms:

CDHF5, HDGC, desmoglein-2, cadherin family member 5

Genomic Location:

Chr 18: 27332170-27380754

Description:

This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature ...

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This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGACGY_E4F1_Q6 ,  CAGGTG_E12_Q6 ,  GGGCGGR_SP1_Q6 ,  AREB6_03 ,  CTTTGT_LEF1_Q2

Cytogenetic Map:

18q12.1

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