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QuickView for dienestrol (compound)
PubChem
| Name: | Dienestrol |
|---|---|
| PubChem Compound ID: | 3049 |
| Description: | A synthetic, non-steroidal estrogen structurally related to stilbestrol. It is used, usually as the cream, in the treatment of menopausal and postmenopausal symptoms. |
| Molecular formula: | C18H18O2 |
| Molecular weight: | 266.334 g/mol |
| Synonyms: |
NINDS_000771; KBio2_001416; DivK1c_000771; Spectrum3_000389; Spectrum2_000971; KBio2_003984; KBioSS_001416; SPBio_002875; Spectrum4_000510; SPBio_001001.
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DrugBank
Identification
| Name: | Dienestrol |
|---|---|
| Name (isomeric): | DB00890 |
| Drug Type: | small molecule |
| Description: | A synthetic, non-steroidal estrogen structurally related to stilbestrol. It is used, usually as the cream, in the treatment of menopausal and postmenopausal symptoms. |
| Synonyms: |
Dehydrostilbestrol; Dienoestrol; Dienesterol; Dehydrostilboestrol
|
| Brand: | Hormofemin, Cycladiene, Synestrol, DV, Dinovex, para-Dien, Dienol, Gynefollin, Oestrovis, Retalon, Dinestrol, Estroral, Restrol, Oestrasid, Willnestrol, Agaldog, Estragard, Sexadien, Oestrodienol, Teserene, Follormon, Dienoestrol BP, Isodienestrol, Estrodienol, Estraguard, Oestroral, Oestrodiene |
| Category: | Estrogens, Non-Steroidal |
| CAS number: | 84-17-3 |
Pharmacology
| Indication: | For use in the treatment of atrophic vaginitis and kraurosis vulvae. |
|---|---|
| Pharmacology: |
Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-st...
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| Mechanism of Action: | Dienestrol is a synthetic, non-steroidal estrogen. Estrogens passively diffuse into target cells of responsive tissues, complex with the estrogen receptors, and enter the cell's nucleus to initiate or enhance gene transcription of protein synthesis after binding to DNA. |
| Absorption: | Systemic absorption and mode of action of dienestrol are undetermined.Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH). |
| Protein binding: | 50 to 80% |
| Biotransformation: | Hepatic. |
| Toxicity: | Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. |
| Affected organisms: | Humans and other mammals |
Targets
