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QuickView for dihydrotachysterol (compound)
PubChem
| Name: | Dihydrotachysterol |
|---|---|
| PubChem Compound ID: | 11953890 |
| Description: | A VITAMIN D that can be regarded as a reduction product of vitamin D2. |
| Molecular formula: | C28H46O |
| Molecular weight: | 398.664 g/mol |
| Synonyms: |
C06957; Hytakerol (TN); Dihydrotachysterol (JAN/USP); 67-96-9; D00299; Dihydrotachysterol; Hytakerol
|
DrugBank
Identification
| Name: | Dihydrotachysterol |
|---|---|
| Name (isomeric): | DB01070 |
| Drug Type: | small molecule |
| Description: | A VITAMIN D that can be regarded as a reduction product of vitamin D2. |
| Synonyms: |
Vitamin D4
|
| Brand: | Tachystin, Antitanil, Parterol, Dygratyl, Calcamine, Hytakerol, Dihydral, Dichystrolum, DHT Intensol |
| Category: | Antihypocalcemic Agents, Antihypoparathyroid Agents, Vitamins, Vitamins (Vitamin D), Bone Density Conservation Agents |
| CAS number: | 67-96-9 |
Pharmacology
| Indication: | Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis). |
|---|---|
| Pharmacology: |
Dihydrotachysterol is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1, 25-dihydroxyvitamin D. Dihydrotachysterol is effective in the elevation of serum calcium by stimulating intestinal calciu...
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| Mechanism of Action: |
Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D receptor. The bound form of the vitamin D receptor serves as a transcriptional regulator of bone matrix proteins, inducing the expression of osteocalcin and suppressing synthesis of type I collagen. Vitamin D (when bound to the vitamin D receptor)stimulates ...
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| Protein binding: | >99% |
| Toxicity: | Toxicity associated with dihydrotachysterol is similar to that seen with large doses of vitamin D. |
| Affected organisms: | Humans and other mammals |
Targets
