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QuickView for fosfomycin (compound)
PubChem
| Name: | Fosfomycin |
|---|---|
| PubChem Compound ID: | 10199068 |
| Description: | An antibiotic produced by Streptomyces fradiae. |
| Molecular formula: | C7H18NO7P |
| Molecular weight: | 259.194 g/mol |
DrugBank
Identification
| Name: | Fosfomycin |
|---|---|
| Name (isomeric): | DB00828 |
| Drug Type: | small molecule |
| Description: | An antibiotic produced by Streptomyces fradiae. |
| Synonyms: |
Phosphomycin; Fosfocina; Fosfomycin sodium; Fosfonomycin; Phosphonomycin; Fosfomycin disodium salt; phosphomycin disodium salt
|
| Brand: | Monurol, Veramina |
| Category: | Anti-Bacterial Agents |
| CAS number: | 23155-02-4 |
Pharmacology
| Indication: | For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of <i>Escherichia coli</i> and <i>Enterococcus faecalis</i>. |
|---|---|
| Pharmacology: | Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. |
| Mechanism of Action: | Fosfomycin is a phosphoenolpyruvate analogue produced by Streptomyces that irreversibly inhibits enolpyruvate transferase (MurA), which prevents the formation of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall. |
| Absorption: | Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30% |
| Protein binding: | 0% (not bound to plasma proteins) |
| Biotransformation: | No transformation, excreted unchanged |
| Route of elimination: | Fosfomycin is excreted unchanged in both urine and feces. |
| Half Life: | 5.7 (± 2.8) hours. The elimination half-life is 40 hours in anuric patients undergoing hemodialysis. |
| Clearance: | 16.9 +/- 3.5 L/hr |
| Toxicity: | LD50>5 g/kg (rats). Side effects may include diarrhea |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Food interaction: |
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Targets
