Bookmark
Forward
QuickView for guanabenz (compound)
PubChem
| Name: | Guanabenz |
|---|---|
| PubChem Compound ID: | 3517 |
| Description: | An alpha-2 selective adrenergic agonist used as an antihypertensive agent. |
| Molecular formula: | C8H8Cl2N4 |
| Molecular weight: | 231.081 g/mol |
| Synonyms: |
Prestwick1_000096; Prestwick0_000096; NINDS_000010; DivK1c_000010; Spectrum3_000445; Spectrum2_001114; KBio1_000010; KBio2_006459; Spectrum4_000567; SPBio_001991.
show more » |
DrugBank
Identification
| Name: | Guanabenz |
|---|---|
| Name (isomeric): | DB00629 |
| Drug Type: | small molecule |
| Description: | An alpha-2 selective adrenergic agonist used as an antihypertensive agent. |
| Brand: | Wy 8678 base, Guanabenzo [INN-Spanish], Wytensin, GBZ, Guanabenz Acetate, Guanabenz [USAN:INN], Guanabenz(USAN), Guanabenzum [INN-Latin] |
| Category: | Sympatholytics, Adrenergic alpha-Agonists, Antihypertensive Agents |
| CAS number: | 5051-62-7 |
Pharmacology
| Indication: | For management of High blood pressure |
|---|---|
| Pharmacology: | Guanabenz, a centrally acting α-2 adrenergic agonist, is indicated for treatment of hypertension. |
| Mechanism of Action: |
Guanabenz's antihypertensive effect is thought to be due to central alpha-adrenergic stimulation, which results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature in addition to a decreased systolic and diastolic blood pressure and a slight slowing of pulse rate. Chronic administration of guanabenz also causes a de...
show more » |
| Absorption: | Approximately 75% absorbed from gastrointestinal tract |
| Protein binding: | 90% |
| Biotransformation: | Hepatic |
| Half Life: | 6 hours. |
| Toxicity: | Excessive contraction of the pupils, irritability, low blood pressure, sleepiness, slow heartbeat, sluggishness |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
|
|---|
Targets
Enzymes
