QuickView for hPrp4 (gene)
- Gene Symbol:
- PRPF4
Homo sapiens - Full name:
- pre-mRNA processing factor 4
- Synonyms:
- HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60, U4/U6 small nuclear ribonucleoprotein Prp4, PRP4 homolog, PRP4 pre-mRNA processing factor 4 homolog, PRP4/STK/WD splicing factor, U4/U6 snRNP 60 kDa protein, WD splicing factor Prp4
- Genomic Location:
- Chr 9: 115077795-115094877
- Description:
-
The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gen...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
9q32
GO Molecular Function
nucleic acid binding | U4 snRNA binding | organic cyclic compound binding | protein binding | snRNA binding | U6 snRNA binding | heterocyclic compound binding | RNA binding
GO Biological Process
RNA metabolic process | RNA processing | cellular process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | RNA splicing | RNA splicing, via transesterification reactions | cellular nitrogen compound metabolic process | mRNA metabolic process | nitrogen compound metabolic process | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | heterocycle metabolic process | cellular metabolic process | mRNA processing | mRNA splicing, via spliceosome | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | small nuclear ribonucleoprotein complex | U4/U6 x U5 tri-snRNP complex | cell | nuclear lumen | spliceosomal snRNP complex | intracellular organelle | Cajal body | nuclear body | protein-containing complex | nucleoplasm | U2-type spliceosomal complex | nuclear speck | ribonucleoprotein complex | spliceosomal complex | U2-type precatalytic spliceosome | membrane-bounded organelle | nucleus | organelle | U4/U6 snRNP | membrane-enclosed lumen | intracellular | precatalytic spliceosome
