QuickView for kb18 (gene)

Gene Symbol:

KRT75 Homo sapiens

Full name:

keratin 75

Synonyms:

K6HF, KB18, PFB, keratin, type II cytoskeletal 75, CK-75, K75, cytokeratin type II, cytokeratin-75, hK6hf, keratin 75, type II, keratin-6 hair follicle, type II keratin-18, type II keratin-K6hf, type-II keratin Kb18

Genomic Location:

Chr 12: 51104121-51114377

Description:

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. Th...

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This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CAGGTG_E12_Q6 ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  MYOGENIN_Q6

Cytogenetic Map:

12q13.13

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