Bookmark
Forward
QuickView for mecamylamine (compound)
PubChem
| Name: | Mecamylamine |
|---|---|
| PubChem Compound ID: | 10932563 |
| Description: | A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. |
| Molecular formula: | C11H21N |
| Molecular weight: | 167.291 g/mol |
DrugBank
Identification
| Name: | Mecamylamine |
|---|---|
| Name (isomeric): | DB00657 |
| Drug Type: | small molecule |
| Description: | A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. |
| Synonyms: |
2-Methylaminoisocamphane; 3-Methylaminoisocamphane hydrochloride; 3-Methylaminoisocamphane; Mecamilamina; 2-Methylamino-2,3,3-trimethylnorbornane; Mecamylamine Hydrochloride
|
| Brand: | Inversine hydrochloride, Revertina, Mekamine, Mecamine hydrochloride, Versamine, Mecamine, Mevasin hydrochloride, Mekamin hydrochloride, Inversine, Mevasine |
| Category: | Ganglionic Blockers, Nicotinic Antagonists, Antihypertensive Agents |
| CAS number: | 60-40-2 |
Pharmacology
| Indication: | For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension |
|---|---|
| Pharmacology: |
Mecamylamine is a potent, oral antihypertensive agent and ganglion blocker, and is a secondary amine. Mecamylamine is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. Mecamylamine reduces blood pressure in both normotensive and hypertensive individuals. A small ...
show more » |
| Mechanism of Action: | Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural. |
| Absorption: | Mecamylamine is almost completely absorbed from the gastrointestinal tract |
| Protein binding: | 40% |
| Route of elimination: | Mecamylamine is excreted slowly in the urine in the unchanged form. The rate of its renal elimination is influenced markedly by urinary pH. Alkalinization of the urine reduces, and acidification promotes, renal excretion of mecamylamine. Mecamylamine crosses the blood-brain and placental barriers. |
| Affected organisms: | Humans and other mammals |
Targets
