QuickView for megalin (gene)

Gene Symbol:

LRP2 Homo sapiens

Full name:

LDL receptor related protein 2

Synonyms:

DBS, GP330, low-density lipoprotein receptor-related protein 2, Heymann nephritis antigen homolog, LRP-2, calcium sensor protein, glycoprotein 330, megalin

Genomic Location:

Chr 2: 169691865-169927368

Description:

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a sho...

View Full Description

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  D. melanogaster

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  MZF1_01 ,  RYTTCCTG_ETS2_B ,  MIF1_01 ,  SMAD3_Q6 ,  STAT6_02 ,  NKX3A_01 ,  ACTTTAT_MIR1425P ,  CTTTGA_LEF1_Q2 ,  CYTAGCAAY_UNKNOWN ,  STAT3_02 ,  GGATTA_PITX2_Q2 ,  FREAC3_01 ,  CDX2_Q5 ,  LHX3_01 ,  GGGCGGR_SP1_Q6 ,  NKX25_02 ,  RNGTGGGC_UNKNOWN ,  TAATTA_CHX10_01 ,  AACATTC_MIR4093P ,  CHOP_01 ,  IK2_01 ,  IK1_01 ,  TGATTTRY_GFI1_01 ,  ICSBP_Q6 ,  ISRE_01 ,  CACBINDINGPROTEIN_Q6 ,  FOXM1_01 ,  PAX4_03 ,  STTTCRNTTT_IRF_Q6 ,  PAX4_01 ,  GGGTGGRR_PAX4_03

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-455

Cytogenetic Map:

2q31.1

search → result