Name: | Aminosalicylic Acid |
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PubChem Compound ID: | 11286589 |
Description: | An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid. |
Molecular formula: | C7H7NO3 |
Molecular weight: | 155.148 g/mol |
Name: | Aminosalicylic Acid |
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Name (isomeric): | DB00233 |
Drug Type: | small molecule |
Description: | An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid. |
Synonyms: |
Para-aminosalicylic acid; PAS; 4-ASA; Para-Amino Salicylic Acid; Amino-PAS; P-Aminosalicylic Acid; PASK; Aminosalicylate Sodium; 4-aminosalicylic acid; APAS
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Brand: | Pasmed, Pasalon, Gabbropas, Neopasalate, Pasnodia, Pasa, Propasa, Sanipriol-4, Aminox, PAS-C, Rezipas, Aminopar, Pasem, Pamisyl, Deapasil, Paser, Parasalindon, Ferrosan, Apacil, Sanipirol-4, Paramycin, Pasdium, Parasalicil, Entepas, Parasal, Para-Pas, Kyselina P-Aminosalicylova, Osacyl, Pamacyl, Pasolac, Pasara, Pascorbic, Hellipidyl |
Category: | Antituberculosis Agents, Antitubercular Agents |
CAS number: | 65-49-6 |
Indication: | For the treatment of tuberculosis |
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Pharmacology: |
Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabol...
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Mechanism of Action: |
There are two mechanisms responsible for aminosalicylic acid's bacteriostatic action against Mycobacterium tuberculosis. Firstly, aminosalicylic acid inhibits folic acid synthesis (without potentiation with antifolic compounds). The binding of para-aminobenzoic acid to pteridine synthetase acts as the first step in folic acid synthesis. Amin...
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Protein binding: | 50-60% |
Biotransformation: | Hepatic. |
Toxicity: | LD50=4 gm/kg (orally in mice); LD50=3650 mg/kg (orally in rabbits) |
Affected organisms: | Mycobacteria |
Food interaction: |
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Drug interaction: |
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