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QuickView for pheniramine (compound)


PubChem
Name: Pheniramine
PubChem Compound ID: 4761
Description: One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.
Molecular formula: C16H20N2
Molecular weight: 240.343 g/mol
Synonyms:
86-21-5; 3-Phenyl-3-(2-pyridyl)-N,N-dimethylpropylanine; BRN 0192445; 2-(3-Dimethylamino-1-phenylpropyl)pyridine; Feniramine; Spectrum3_000760; 2-(alpha-(2-Dimethylaminoethyl)benzyl)pyridine; Pheniraminum [INN-Latin]; KBio3_001600; KBio1_000235.
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DrugBank
Identification
Name: Pheniramine
Name (isomeric): DB01620
Drug Type: small molecule
Description: One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.
Synonyms:
2-(alpha-(2-Dimethylaminoethyl)benzyl)pyridine; Prophenpyridamine; Feniramina [inn-spanish]; 2-[.alpha.-[2-(Dimethylamino)ethyl]benzyl]pyridine; 1-Phenyl-1-(2-pyridyl)-3-dimethylaminopropane; 2-(3-Dimethylamino-1-phenylpropyl)pyridine; Propheniramine; Feniramine; 2-[.alpha.-(2-Dimethylaminoethyl)benzyl]pyridine; Dimethyl(3-phenyl-3-(2-pyridyl)propyl)amine.
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Brand: Tripoton, Metron, Inhiston, Trimeton, AVIL, Pyriton
Brand name mixture:
Hot Lemon Cough and Colds Relief DM(Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylephrine Hydrochloride), AK Vernacon Oph Solution(Pheniramine Maleate + Phenylephrine Hydrochloride), Visine Advance Allergy(Naphazoline Hydrochloride + Pheniramine Maleate), Diorouge Liquid(Pheniramine Maleate + Phenylephrine Hydrochloride + Polyvinyl...
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Category: Histamine H1 Antagonists, Antipruritics, Anti-Allergic Agents, Antipruritic Agents
CAS number: 86-21-5
Pharmacology
Indication: Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria.
Pharmacology:
Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria. It is generally sold in combination with other medications, rather than as a stand-alone drug. Allergies are caused by an excessive type 1 hypersensitivity response of the body to allergens, mediated by inappropriate histamine signalling. By inhibiting...
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Mechanism of Action:
Antihistamines such as pheniramine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving hista...
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Biotransformation: Hepatic hydroxylation, demethylation and glucuronidation.
Affected organisms: Humans and other mammals

Targets