Name: | Pheniramine |
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PubChem Compound ID: | 4761 |
Description: | One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. |
Molecular formula: | C16H20N2 |
Molecular weight: | 240.343 g/mol |
Synonyms: |
86-21-5; 3-Phenyl-3-(2-pyridyl)-N,N-dimethylpropylanine; BRN 0192445; 2-(3-Dimethylamino-1-phenylpropyl)pyridine; Feniramine; Spectrum3_000760; 2-(alpha-(2-Dimethylaminoethyl)benzyl)pyridine; Pheniraminum [INN-Latin]; KBio3_001600; KBio1_000235.
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Name: | Pheniramine |
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Name (isomeric): | DB01620 |
Drug Type: | small molecule |
Description: | One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. |
Synonyms: |
2-(alpha-(2-Dimethylaminoethyl)benzyl)pyridine; Prophenpyridamine; Feniramina [inn-spanish]; 2-[.alpha.-[2-(Dimethylamino)ethyl]benzyl]pyridine; 1-Phenyl-1-(2-pyridyl)-3-dimethylaminopropane; 2-(3-Dimethylamino-1-phenylpropyl)pyridine; Propheniramine; Feniramine; 2-[.alpha.-(2-Dimethylaminoethyl)benzyl]pyridine; Dimethyl(3-phenyl-3-(2-pyridyl)propyl)amine.
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Brand: | Tripoton, Metron, Inhiston, Trimeton, AVIL, Pyriton |
Brand name mixture: | Hot Lemon Cough and Colds Relief DM(Dextromethorphan Hydrobromide + Pheniramine Maleate + Phenylephrine Hydrochloride), AK Vernacon Oph Solution(Pheniramine Maleate + Phenylephrine Hydrochloride), Visine Advance Allergy(Naphazoline Hydrochloride + Pheniramine Maleate), Diorouge Liquid(Pheniramine Maleate + Phenylephrine Hydrochloride + Polyvinyl... show more » |
Category: | Histamine H1 Antagonists, Antipruritics, Anti-Allergic Agents, Antipruritic Agents |
CAS number: | 86-21-5 |
Indication: | Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria. |
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Pharmacology: |
Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria. It is generally sold in combination with other medications, rather than as a stand-alone drug. Allergies are caused by an excessive type 1 hypersensitivity response of the body to allergens, mediated by inappropriate histamine signalling. By inhibiting...
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Mechanism of Action: |
Antihistamines such as pheniramine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving hista...
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Biotransformation: | Hepatic hydroxylation, demethylation and glucuronidation. |
Affected organisms: | Humans and other mammals |