QuickView for pigA (gene)

Gene Symbol:

PIGA Homo sapiens

Full name:

phosphatidylinositol glycan anchor biosynthesis class A

Synonyms:

GPI3, MCAHS2, PIG-A, PNH1, phosphatidylinositol N-acetylglucosaminyltransferase subunit A, GLCNAC-PI synthesis protein, GPI anchor biosynthesis, class A GlcNAc-inositol phospholipid assembly protein, phosphatidylinositol-glycan biosynthesis, class A protein

Genomic Location:

Chr X: 15247499-15263581

Description:

This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic ...

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This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Bos taurus ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  MCAATNNNNNGCG_UNKNOWN ,  NFY_C ,  CCTGAGT_MIR510 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TTGCACT_MIR130A_MIR301_MIR130B ,  ZIC3_01 ,  RFX1_01 ,  TTGGGAG_MIR150 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  GGCNKCCATNK_UNKNOWN ,  ACTGAAA_MIR30A3P_MIR30E3P ,  TTGCCAA_MIR182 ,  CAAGGAT_MIR362 ,  TGCTTTG_MIR330 ,  TGCACTT_MIR519C_MIR519B_MIR519A

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-448

Cytogenetic Map:

Xp22.2

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