Name: | Procarbazine |
---|---|
PubChem Compound ID: | 175791 |
Description: | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. |
Molecular formula: | C12H19N3O |
Molecular weight: | 223.311 g/mol |
Synonyms: |
98600-73-8; N-(1-Methylethyl)-4-((2-methylhydrazino)methyl-d2)benzamide; Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl-d2)-
|
Name: | Procarbazine |
---|---|
Name (isomeric): | DB01168 |
Drug Type: | small molecule |
Description: | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. |
Synonyms: |
IBZ; Procarbazine hydrochloride; MIH Hydrochloride; PCX; Ibenzmethyzine hydrochloride; MIH; PCB; PCB hydrochloride; MBH; Procarbazina [INN-Spanish].
show more » |
Brand: | Matulane, Natulan hydrochloride, Nathulane, Natulanar, Natunalar, Natulan |
Category: | Antineoplastic Agents |
CAS number: | 671-16-9 |
Indication: | For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease. |
---|---|
Pharmacology: |
Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly a...
show more » |
Mechanism of Action: |
The precise mode of cytotoxic action of procarbazine has not been clearly defined. There is evidence that the drug may act by inhibition of protein, RNA and DNA synthesis. Studies have suggested that procarbazine may inhibit transmethylation of methyl groups of methionine into t-RNA. The absence of functional t-RNA could cause the cessation of prot...
show more » |
Absorption: | Procarbazine is rapidly and completely absorbed. |
Biotransformation: | Procarbazine is metabolized primarily in the liver and kidneys. The drug appears to be auto-oxidized to the azo derivative with the release of hydrogen peroxide. The azo derivative isomerizes to the hydrazone, and following hydrolysis splits into a benzylaldehyde derivative and methylhydrazine. The methylhydrazine is further degraded to CO2 and CH4 and possibly hydrazine, whereas the aldehyde is oxidized to N-isopropylterephthalamic acid, which is excreted in the urine. |
Half Life: | 10 minutes |
Toxicity: | LD50=785 mg/kg (orally in rats) |
Affected organisms: | Humans and other mammals |
Drug interaction: |
|
---|