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QuickView for spectinomycin (compound)
PubChem
| Name: | Spectinomycin |
|---|---|
| PubChem Compound ID: | 15541 |
| Description: | An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea. |
| Molecular formula: | C14H24N2O7 |
| Molecular weight: | 332.35 g/mol |
| Synonyms: |
Spectinomicina [Italian]; 22189-32-8; SPBio_001409; SPECTINOMYCIN; XK 43-1; 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-; EINECS 216-911-3; Prestwick0_000804; Prestwick1_000804; NCI60_000023.
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DrugBank
Identification
| Name: | Spectinomycin |
|---|---|
| Name (isomeric): | DB00919 |
| Drug Type: | small molecule |
| Description: | An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea. |
| Synonyms: |
Antibiotic 2233wp; Spectinomicina [Italian]; Spectinomycinum [INN-Latin]; Espectinomicina [INN-Spanish]; Spectinomycin Di HCl; Spectinomycine [INN-French]; SCM; Spectinomycin HCl/ Sulphate; Actinospectacina [Italian]
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| Brand: | Spectam, Actinospectacin, Trobicin, Togamycin |
| Brand name mixture: | Lincomycin Spectinomycin 100 Soluble Powder(Lincomycin (Lincomycin Hydrochloride) + Spectinomycin (Spectinomycin Hydrochloride)), Lincomycin Spectinomycin 4.4% G Premix(Lincomycin (Lincomycin Hydrochloride) + Spectinomycin (Spectinomycin Hydrochloride)), L-S 100 Soluble Powder(Lincomycin (Lincomycin Hydrochloride) + Spectinomycin (Spectinomycin ... show more » |
| Category: | Anti-Bacterial Agents, Aminoglycosides |
| CAS number: | 1695-77-8 |
Pharmacology
| Indication: | For use in the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of <i>Neisseria gonorrhoeae</i>. |
|---|---|
| Pharmacology: |
Spectinomycin is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts...
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| Mechanism of Action: | Spectinomycin is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. It is bactericidal in its action. |
| Absorption: | Rapidly and almost completely absorbed after intramuscular injection. |
| Protein binding: | Not significant |
| Half Life: | 1 to 3 hours in patients with normal renal function and 10 to 30 hours in patients with impaired renal function with a creatinine clearance < 20 mL per minute. |
| Toxicity: | Acute oral toxicity (LD50): >5000 mg/kg [Rat]. Information on overdosage in humans is not available. |
| Affected organisms: | Enteric bacteria and other eubacteria |
Targets
