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QuickView for tetrahydrofolate (compound)
PubChem
| Name: | 5,6,7,8-tetrahydrofolic acid |
|---|---|
| PubChem Compound ID: | 1129 |
| Molecular formula: | C19H23N7O6 |
| Molecular weight: | 445.43 g/mol |
| Synonyms: |
C00101; Tetrahydrofolic acid; tetra-H-folate; 29347-89-5; H4PteGlu1; (6S)-Tetrahydrofolic acid; glutamic acid, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-; DL-Glutamic acid, N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-; Tetrahydrofolate; 5,6,7,8-Tetrahydrofolic acid.
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DrugBank
Identification
| Name: | 5,6,7,8-tetrahydrofolic acid |
|---|---|
| Name (isomeric): | DB00116 |
| Drug Type: | small molecule |
| Synonyms: |
5,6,7,8-tetrahydrofolic acid; tetra-H-folate; 5,6,7,8-tetrahydrofolate; tetrahydrofolate; N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)glutamic acid; THF; FH4; tetrahydrafolate; tetrahydropteroylglutamate; (6S)-tetrahydrofolate.
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| Category: | Micronutrient, Dietary supplement |
| CAS number: | 135-16-0 |
Pharmacology
| Indication: | For nutritional supplementation, also for treating dietary shortage or imbalance. |
|---|---|
| Pharmacology: |
Tetrahydrofolate is the main active metabolite of dietary folate. It is vital as a coenzyme in reactions involving transfers of single carbon groups. Tetrahydrofolate has a role in nucleic and amino acid synthesis. As nucleic and amino acid synthesis is affected by a deficiency of tetrahydrofolate, actively dividing and growing cells tend to be the...
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| Mechanism of Action: | Tetrahydrofolate is transported across cells by receptor-mediated endocytosis where it is needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. |
| Affected organisms: | Humans and other mammals |
Targets
Transporters
