QuickView for vimentin (gene)

Gene Symbol:

VIM Homo sapiens

Full name:

vimentin

Synonyms:

vimentin

Genomic Location:

Chr 10: 17311304-17319598

Description:

This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and choles...

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This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  AML_Q6 ,  AP1_Q6 ,  AML1_01 ,  GGGAGGRR_MAZ_Q6 ,  GGGYGTGNY_UNKNOWN ,  RREB1_01 ,  AP1FJ_Q2 ,  GGGCGGR_SP1_Q6 ,  AP1_Q4 ,  GTGCCTT_MIR506 ,  AML1_Q6 ,  AP2REP_01 ,  WTTGKCTG_UNKNOWN ,  RGAGGAARY_PU1_Q6 ,  AP1_Q2 ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  COREBINDINGFACTOR_Q6 ,  ELF1_Q6 ,  RRCCGTTA_UNKNOWN ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-124a

Cytogenetic Map:

10p13

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