QuickView for ADRA2A;jsessionid=289AEAA91BF28C0C1B47712D8D590392;jsessionid=A25D6A331F0A789D44431BFF5DDAD4C2;jsessionid=BEF644CDDD4231C480707F334C7711DB (gene)
- Gene Symbol:
- ADRA2A
Homo sapiens - Full name:
- adrenoceptor alpha 2A
- Synonyms:
- ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32, alpha-2A adrenergic receptor, adrenergic, alpha-2A-, receptor, alpha-2 adrenergic receptor subtype C10, alpha-2-adrenergic receptor, platelet type, alpha-2A adrenoceptor, alpha-2A adrenoreceptor, alpha-2AAR subtype C10
- Genomic Location:
- Chr 10: 112826911-112830560
- Description:
-
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed tha...
- Orthologs:
- Mus musculus , Rattus norvegicus , C. elegans , Macaca mulatta , Danio rerio , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
10q25.2
GO Molecular Function
alpha-1B adrenergic receptor binding | kinase binding | epinephrine binding | heterotrimeric G-protein binding | protein kinase binding | alpha-adrenergic receptor activity | transmembrane signaling receptor activity | enzyme binding | protein-containing complex binding | G-protein coupled receptor activity | signaling receptor binding | G-protein coupled amine receptor activity | adrenergic receptor binding | adrenergic receptor activity | signaling receptor activity | identical protein binding | protein heterodimerization activity | thioesterase binding | organic cyclic compound binding | alpha2-adrenergic receptor activity | alpha-2C adrenergic receptor binding | protein binding | protein homodimerization activity | protein dimerization activity | G-protein coupled receptor binding | norepinephrine binding
GO Biological Process
regulation of blood vessel diameter | regulation of muscle system process | positive regulation of locomotion | actin filament-based process | regulation of cellular localization | negative regulation of peptide secretion | intracellular signal transduction | regulation of localization | positive regulation of peptidyl-tyrosine phosphorylation | actin cytoskeleton organization | establishment of localization | response to hormone | negative regulation of cellular process | regulation of MAP kinase activity | positive regulation of signaling receptor activity | regulation of smooth muscle contraction | positive regulation of protein catabolic process | glucose homeostasis | positive regulation of phosphate metabolic process | negative regulation of protein secretion | positive regulation of cellular component movement | regulation of peptide hormone secretion | cellular process | regulation of catecholamine secretion | positive regulation of epidermal growth factor-activated receptor activity | regulation of cell motility | localization | negative regulation of signaling | positive regulation of protein kinase activity | hemostasis | negative regulation of secretion | regulation of proteolysis | alpha-adrenergic receptor activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of hormone secretion | negative regulation of establishment of protein localization | regulation of cellular process | regulation of metabolic process | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | cellular component organization | positive regulation of potassium ion transport | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | G-protein coupled receptor activity | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | phospholipase C-activating adrenergic receptor signaling pathway | regulation of peptidyl-tyrosine phosphorylation | regulation of insulin secretion | positive regulation of protein metabolic process | regulation of blood vessel size | regulation of norepinephrine secretion | response to stress | adenylate cyclase-activating adrenergic receptor signaling pathway | positive regulation of membrane protein ectodomain proteolysis | regulation of cell proliferation | regulation of blood circulation | G-protein coupled amine receptor activity | negative regulation of transporter activity | positive regulation of proteolysis | negative regulation of transport | regulation of protein transport | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | regulation of wound healing | regulation of peptide transport | negative regulation of calcium ion transmembrane transport | negative regulation of transmembrane transport | activation of protein kinase activity | positive regulation of ERBB signaling pathway | blood coagulation | cellular response to hormone stimulus | regulation of protein tyrosine kinase activity | adrenergic receptor activity | positive regulation of response to wounding | negative regulation of epinephrine secretion | regulation of signal transduction | negative regulation of secretion by cell | regulation of MAPK cascade | negative regulation of lipid catabolic process | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | adenylate cyclase-inhibiting adrenergic receptor signaling pathway | regulation of muscle contraction | regulation of catalytic activity | regulation of insulin secretion involved in cellular response to glucose stimulus | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | wound healing | platelet activation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | digestive system process | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of intracellular signal transduction | receptor transactivation | regulation of cellular component movement | negative regulation of norepinephrine secretion | second-messenger-mediated signaling | activation of protein kinase B activity | positive regulation of cell migration | negative regulation of ion transmembrane transport | intestinal absorption | negative regulation of calcium ion transmembrane transporter activity | regulation of cellular protein metabolic process | negative regulation of peptide hormone secretion | negative regulation of ion transport | regulation of calcium ion transmembrane transport | alpha2-adrenergic receptor activity | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of lipid catabolic process | negative regulation of calcium ion transport | cyclic-nucleotide-mediated signaling | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of tube size | positive regulation of transport | negative regulation of insulin secretion involved in cellular response to glucose stimulus | coagulation | negative regulation of catecholamine secretion | regulation of potassium ion transport | positive regulation of molecular function | negative regulation of exocytosis | regulation of signaling receptor activity | regulation of epidermal growth factor-activated receptor activity | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | Rho protein signal transduction | cAMP-mediated signaling | regulation of kinase activity | response to wounding | regulation of intracellular signal transduction | regulation of exocytosis | regulation of vasoconstriction | negative regulation of lipid metabolic process | regulation of protein catabolic process | regulation of body fluid levels | regulation of tube diameter | regulation of vesicle-mediated transport | chemical homeostasis | regulation of secretion | negative regulation of ion transmembrane transporter activity | regulation of epidermal growth factor receptor signaling pathway | positive regulation of ion transport | regulation of protein secretion | positive regulation of kinase activity | regulation of phosphate metabolic process | positive regulation of wound healing | cytoskeleton organization | regulation of ion transmembrane transport | phospholipase C-activating G-protein coupled receptor signaling pathway | positive regulation of cytokine production | regulation of regulated secretory pathway | cell activation | positive regulation of MAPK cascade | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of response to wounding | regulation of cell communication | negative regulation of molecular function | negative regulation of insulin secretion | signaling | regulation of ERBB signaling pathway | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | positive regulation of protein tyrosine kinase activity | positive regulation of epidermal growth factor receptor signaling pathway | regulation of cytokine production | positive regulation of MAP kinase activity | regulation of ion transport | negative regulation of calcium ion-dependent exocytosis | organelle organization | regulation of calcium ion transport | digestion | regulation of transport | adrenergic receptor signaling pathway | Ras protein signal transduction | regulation of calcium ion-dependent exocytosis | regulation of lipid metabolic process | positive regulation of metabolic process | regulation of calcium ion transmembrane transporter activity | cellular response to organic substance | regulation of protein localization | positive regulation of cell motility | carbohydrate homeostasis | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | cytoplasm | receptor complex | protein-containing complex | plasma membrane | integral component of plasma membrane | cell periphery | basolateral plasma membrane | intracellular | membrane | intrinsic component of plasma membrane
