QuickView for APB-3;jsessionid=C06CB3C0DAE6EB9C9BC3EA9E49F8A824;jsessionid=8BBF209A38CCFA89F4228663E93A3A4F;jsessionid=C46E3E5DAD4B1B6FAC0A7DB35784D0CC;jsessionid=209804BEE53655598CE74F0DEB50D335 (gene)

Gene Symbol:

AP3B2 Homo sapiens

Full name:

adaptor related protein complex 3 beta 2 subunit

Synonyms:

EIEE48, NAPTB, AP-3 complex subunit beta-2, Neuronal adaptin-like protein, beta-subunit, adaptor protein complex AP-3 subunit beta-2, adaptor-related protein complex 3 subunit beta-2, beta-3B-adaptin, clathrin assembly protein complex 3 beta-2 large chain, neuron-specific vesicle coat protein beta-NAP

Genomic Location:

Chr 15: 81125088-81175689

Description:

Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit...

View Full Description

Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat assembly. Defects in this gene are a cause of early-onset epileptic encephalopathy.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes ,  Gallus gallus ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTTGA_LEF1_Q2 ,  RNGTGGGC_UNKNOWN

Cytogenetic Map:

15q25.2

search → result