QuickView for ATP4A;jsessionid=8B0EEC11CAE422ADBD1F18D06986ADAE;jsessionid=D9D578621254050BE64157B0F9E7529D;jsessionid=9329A96CF6A7F03258B3C8D810665540;jsessionid=ED8E4DF7F3EF45B1F11BAF52DA2683F6;jsessionid=A733F7271E12AB385A37264DB9DC9A68 (gene)
- Gene Symbol:
- ATP4A
Homo sapiens - Full name:
- ATPase H+/K+ transporting alpha subunit
- Synonyms:
- ATP6A, potassium-transporting ATPase alpha chain 1, ATPase, H+/K+ exchanging, alpha polypeptide, ATPase, H+/K+ transporting, alpha polypeptide, gastric H+/K+ ATPase alpha subunit, gastric H,K-ATPase catalytic subunit, gastric hydrogen-potassium ATPase, proton pump
- Genomic Location:
- Chr 19: 40732935-40746400
- Description:
-
The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
19q13.12
GO Molecular Function
potassium-transporting ATPase activity | ATPase activity, coupled to transmembrane movement of substances | proton transmembrane transporter activity | cation binding | magnesium ion binding | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | ribonucleotide binding | transmembrane transporter activity | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | cation transmembrane transporter activity | ATPase activity, coupled | cation-transporting ATPase activity | active transmembrane transporter activity | purine nucleotide binding | transporter activity | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | metal ion transmembrane transporter activity | potassium ion transmembrane transporter activity | hydrolase activity, acting on acid anhydrides | sodium ion transmembrane transporter activity | ATPase coupled ion transmembrane transporter activity | inorganic cation transmembrane transporter activity | purine ribonucleotide binding | monovalent inorganic cation transmembrane transporter activity | adenyl ribonucleotide binding | drug binding | sodium:potassium-exchanging ATPase activity | metal ion binding | heterocyclic compound binding | potassium:proton exchanging ATPase activity | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding
GO Biological Process
potassium-transporting ATPase activity | ATP hydrolysis coupled cation transmembrane transport | ATPase activity, coupled to transmembrane movement of substances | establishment of localization | proton transmembrane transporter activity | cellular chemical homeostasis | cellular process | proton transmembrane transport | localization | cellular homeostasis | metal ion transport | cellular sodium ion homeostasis | establishment or maintenance of transmembrane electrochemical gradient | sodium ion export across plasma membrane | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | transmembrane transporter activity | ATP hydrolysis coupled transmembrane transport | metal ion homeostasis | sodium ion homeostasis | potassium ion import | ATP hydrolysis coupled ion transmembrane transport | ion transmembrane transport | sodium ion transport | cation transmembrane transporter activity | cellular ion homeostasis | cation-transporting ATPase activity | monovalent inorganic cation transport | active transmembrane transporter activity | cellular potassium ion transport | ion transmembrane transporter activity | potassium ion transport | ATP hydrolysis coupled proton transport | cation homeostasis | cellular cation homeostasis | potassium ion homeostasis | homeostatic process | cation transmembrane transport | cellular potassium ion homeostasis | metal ion transmembrane transporter activity | potassium ion transmembrane transporter activity | chemical homeostasis | sodium ion transmembrane transport | energy coupled proton transmembrane transport, against electrochemical gradient | ion homeostasis | sodium ion transmembrane transporter activity | inorganic cation transmembrane transport | ATPase coupled ion transmembrane transporter activity | transmembrane transport | inorganic cation transmembrane transporter activity | cellular monovalent inorganic cation homeostasis | monovalent inorganic cation transmembrane transporter activity | cation transport | sodium:potassium-exchanging ATPase activity | potassium ion transmembrane transport | cellular metal ion homeostasis | ion transport | potassium:proton exchanging ATPase activity
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | plasma membrane | integral component of plasma membrane | extracellular region | extracellular space | cell periphery | membrane | intrinsic component of plasma membrane
