QuickView for Abcb4;jsessionid=E24E5F1D7E46505A823B05138286EF3A;jsessionid=95B88C3B2004533290B5ED3D4E97E37A (gene)
- Gene Symbol:
- Abcb4
Rattus norvegicus - Full name:
- ATP binding cassette subfamily B member 4
- Synonyms:
- Mdr2, Pgy3, phosphatidylcholine translocator ABCB4, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2), ATP-binding cassette sub-family B member 4, ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2), ATP-binding cassette, subfamily B (MDR/TAP), member 4, P-glycoprotein 2, P-glycoprotein 3, P-glycoprotein 3/ multidrug resistance 2, multidrug resistance protein 2, multidrug resistance protein 3
- Genomic Location:
- Chr 4: 21946272-22004328
- Description:
-
energy-dependent efflux pump; may be involved in changes in bile formation in response to diabetes
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , Macaca mulatta , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
ATPase activity, coupled to transmembrane movement of substances | phosphatidylcholine-translocating ATPase activity | xenobiotic transmembrane transporter activity | ribonucleotide binding | transmembrane transporter activity | sphingolipid transporter activity | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | catalytic activity | ATP binding | phospholipid transporter activity | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | active transmembrane transporter activity | purine nucleotide binding | transporter activity | phosphatidylcholine transporter activity | ion binding | organic cyclic compound binding | drug transmembrane transporter activity | purine ribonucleoside triphosphate binding | protein binding | ceramide-translocating ATPase activity | ceramide transporter activity | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | xenobiotic transmembrane transporting ATPase activity | lipid transporter activity | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding | phospholipid-translocating ATPase activity
GO Biological Process
positive regulation of cellular component organization | regulation of cholesterol transport | regulation of localization | lipid transport | ATPase activity, coupled to transmembrane movement of substances | establishment of localization | response to hormone | phosphatidylcholine-translocating ATPase activity | response to bile acid | response to drug | xenobiotic transmembrane transporter activity | membrane organization | regulation of lipid transport | cellular process | secretion | monocarboxylic acid transport | localization | ceramide translocation | anion transport | macromolecule localization | regulation of membrane lipid distribution | regulation of cellular process | cellular response to lipid | transmembrane transporter activity | response to ether | sphingolipid transporter activity | cellular component organization | response to stimulus | acid secretion | sphingolipid translocation | cellular response to organic cyclic compound | phospholipid transporter activity | organic substance transport | response to ketone | response to lipid | active transmembrane transporter activity | bile acid secretion | response to corticosteroid | organic acid transport | positive regulation of cholesterol transport | organic anion transport | ceramide transport | phosphatidylcholine transporter activity | positive regulation of lipid localization | cellular response to bile acid | response to xenobiotic stimulus | positive regulation of phospholipid translocation | drug transmembrane transporter activity | response to fenofibrate | homeostatic process | positive regulation of transport | phospholipid transport | ceramide-translocating ATPase activity | response to organic substance | xenobiotic transport | lipid localization | amide transport | chemical homeostasis | ceramide transporter activity | positive regulation of ion transport | drug transport | transmembrane transport | response to organic cyclic compound | drug transmembrane transport | carboxylic acid transport | positive regulation of phospholipid transport | regulation of phospholipid translocation | regulation of ion transport | positive regulation of anion transport | phospholipid translocation | xenobiotic transmembrane transporting ATPase activity | regulation of transport | regulation of anion transport | lipid transporter activity | ion transport | positive regulation of lipid transport | cellular response to organic substance | response to steroid hormone | lipid homeostasis | regulation of cellular component organization | response to glucocorticoid | phospholipid-translocating ATPase activity
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | apical plasma membrane | adherens junction | organelle membrane | clathrin-coated vesicle | focal adhesion | cytoplasmic vesicle | cell | nuclear lumen | intrinsic component of membrane | cytoplasm | intercellular canaliculus | cell-substrate junction | intracellular organelle | actin cytoskeleton | membrane microdomain | apical part of cell | cell-cell junction | Golgi apparatus | endomembrane system | nucleoplasm | plasma membrane | membrane raft | vesicle | Golgi membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cell-substrate adherens junction | cytosol | intracellular vesicle | cytoskeleton | intracellular | cell junction | membrane | coated vesicle
