QuickView for Ap2;jsessionid=08AB610AF737F4BB034F1EF0500AE13B;jsessionid=3280104028D30963B2236DE6C860FA76 (gene)
- Gene Symbol:
- AP2A2
Homo sapiens - Full name:
- adaptor related protein complex 2 alpha 2 subunit
- Synonyms:
- ADTAB, CLAPA2, HIP-9, HIP9, HYPJ, AP-2 complex subunit alpha-2, 100 kDa coated vesicle protein C, adapter-related protein complex 2 subunit alpha-2, adaptin, alpha B, adaptor-related protein complex 2 subunit alpha-2, alpha-adaptin C; Huntingtin interacting protein J, alpha2-adaptin, clathrin assembly protein complex 2 alpha-C large chain, clathrin-associated/assembly/adaptor protein, large, alpha 2, huntingtin yeast partner J, huntingtin-interacting protein 9, plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
- Genomic Location:
- Chr 11: 915841-1002240
- Description:
-
The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cel...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
11p15.5
GO Molecular Function
kinase binding | clathrin binding | protein kinase binding | enzyme binding | disordered domain specific binding | lipid binding | protein domain specific binding | protein binding, bridging | endocytic adaptor activity | molecular adaptor activity | protein binding | clathrin adaptor activity | cargo receptor activity
GO Biological Process
exocytosis | antigen processing and presentation | neutrophil activation | establishment of localization | membrane organization | intracellular transport | cellular process | secretion | organic substance catabolic process | leukocyte degranulation | localization | protein transport | macromolecule localization | establishment of localization in cell | interspecies interaction between organisms | regulation of cellular process | leukocyte activation | catabolic process | low-density lipoprotein receptor particle metabolic process | regulation of establishment of planar polarity | ephrin receptor signaling pathway | cellular component organization | response to stimulus | neutrophil degranulation | intracellular protein transport | leukocyte activation involved in immune response | regulation of plasma lipoprotein particle levels | cellular protein catabolic process | cellular localization | secretion by cell | antigen processing and presentation of exogenous peptide antigen via MHC class II | Wnt signaling pathway, planar cell polarity pathway | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | nitrogen compound metabolic process | Wnt signaling pathway | antigen processing and presentation of peptide antigen via MHC class II | leukocyte mediated immunity | organic substance transport | protein catabolic process | endocytic adaptor activity | enzyme linked receptor protein signaling pathway | peptide transport | vesicle-mediated transport | non-canonical Wnt signaling pathway | regulated exocytosis | plasma lipoprotein particle clearance | cell communication | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | viral process | antigen processing and presentation of exogenous antigen | protein metabolic process | receptor catabolic process | regulation of animal organ morphogenesis | import into cell | cellular macromolecule catabolic process | cell surface receptor signaling pathway | metabolic process | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | regulation of defense response to virus by virus | cellular protein localization | amide transport | endocytosis | clathrin-dependent endocytosis | immune response | organic substance metabolic process | establishment of protein localization | cell activation | organonitrogen compound catabolic process | signaling | clathrin adaptor activity | protein localization | cellular protein metabolic process | cellular macromolecule localization | regulation of developmental process | receptor-mediated endocytosis | receptor metabolic process | neutrophil mediated immunity | antigen processing and presentation of peptide antigen | transmembrane receptor protein tyrosine kinase signaling pathway | cargo receptor activity | immune system process | cellular metabolic process | low-density lipoprotein particle clearance | low-density lipoprotein particle receptor catabolic process | signal transduction | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
secretory granule | clathrin coat of endocytic vesicle | endolysosome | intracellular membrane-bounded organelle | clathrin-coated endocytic vesicle membrane | endocytic vesicle membrane | clathrin-coated vesicle membrane | organelle membrane | vesicle coat | clathrin-coated vesicle | clathrin coat of coated pit | tertiary granule | cytoplasmic vesicle | cell | plasma membrane protein complex | AP-2 adaptor complex | cytoplasm | clathrin-coated endocytic vesicle | intracellular organelle | secretory granule membrane | ficolin-1-rich granule membrane | AP-type membrane coat adaptor complex | endosome membrane | protein-containing complex | clathrin adaptor complex | secretory vesicle | endomembrane system | plasma membrane | vacuole | vesicle | clathrin-coated pit | lytic vacuole | endosome | coated vesicle membrane | membrane-bounded organelle | clathrin coat | organelle | vesicle membrane | lysosome | cell periphery | clathrin vesicle coat | endolysosome membrane | cytosol | intracellular vesicle | endocytic vesicle | intracellular | lysosomal membrane | membrane | cytoplasmic vesicle membrane | membrane coat | vacuolar membrane | coated vesicle
