QuickView for BRAF;jsessionid=2547D466A978ABBB1602416142B7EAE5;jsessionid=DB8C3B61C62A76DDE4B68BB701ECDB69;jsessionid=CAF857554EE36718F35BD1E228EBC51D;jsessionid=89A8D3243128A4CCBF1A134BCAAFC750 (gene)

Gene Symbol:

BRAF Homo sapiens

Full name:

B-Raf proto-oncogene, serine/threonine kinase

Synonyms:

B-RAF1, B-raf, BRAF1, NS7, RAFB1, serine/threonine-protein kinase B-raf, 94 kDa B-raf protein, B-Raf proto-oncogene serine/threonine-protein kinase (p94), B-Raf serine/threonine-protein, murine sarcoma viral (v-raf) oncogene homolog B1, proto-oncogene B-Raf, v-raf murine sarcoma viral oncogene homolog B, v-raf murine sarcoma viral oncogene homolog B1

Genomic Location:

Chr 7: 140080751-140271033

Description:

This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations ...

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This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  RTAAACA_FREAC2_01 ,  FREAC7_01 ,  TCANNTGAY_SREBP1_01 ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  RYTTCCTG_ETS2_B ,  YTATTTTNR_MEF2_02 ,  ATF4_Q2 ,  CREB_Q4 ,  TGACCTY_ERR1_Q2 ,  TGAYRTCA_ATF3_Q6 ,  CREBP1_Q2 ,  TATAAA_TATA_01 ,  FOXO3_01 ,  GTGACGY_E4F1_Q6 ,  FREAC3_01 ,  P53_02 ,  RFX1_02 ,  AP1FJ_Q2 ,  CREB_02 ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  E4F1_Q6 ,  E2F1_Q3_01 ,  FREAC2_01 ,  PIT1_Q6 ,  CREB_Q2 ,  RGAGGAARY_PU1_Q6 ,  TGACGTCA_ATF3_Q6 ,  T3R_Q6 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  TBP_01 ,  ER_Q6_02 ,  PAX3_B ,  ER_Q6 ,  ELF1_Q6 ,  CREB_Q2_01 ,  CEBPGAMMA_Q6 ,  CREB_01 ,  FREAC4_01 ,  TAXCREB_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-9

Cytogenetic Map:

7q34

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