QuickView for CDKN1A;jsessionid=3BFFDDD4D50280DF45DAB6967EEA1A85 (gene)
- Gene Symbol:
- Cdkn1a
Rattus norvegicus - Full name:
- cyclin-dependent kinase inhibitor 1A
- Synonyms:
- Cip1, UV96, Waf1, cyclin-dependent kinase inhibitor 1, cyclin-dependent kinase inhibitor 1A (P21), cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- Genomic Location:
- Chr 20: 7376325-7386778
- Description:
-
a Cdk inhibitor; involved in negative regulation of the cell cycle
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
protein kinase activator activity | kinase binding | enzyme activator activity | protein kinase regulator activity | cyclin binding | protein serine/threonine kinase inhibitor activity | kinase regulator activity | protein kinase inhibitor activity | protein kinase binding | enzyme binding | protein-containing complex binding | enzyme inhibitor activity | cyclin-dependent protein kinase activity | protein serine/threonine kinase activity | molecular function regulator | catalytic activity | ubiquitin-like protein ligase binding | cyclin-dependent protein kinase activating kinase activity | protein binding | kinase inhibitor activity | ubiquitin protein ligase binding | cyclin-dependent protein serine/threonine kinase activity | kinase activator activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | enzyme regulator activity | kinase activity | cyclin-dependent protein serine/threonine kinase inhibitor activity | cyclin-dependent protein serine/threonine kinase regulator activity
GO Biological Process
response to extracellular stimulus | negative regulation of phosphorylation | response to radiation | regulation of cell cycle process | protein kinase activator activity | regulation of intracellular protein transport | response to nutrient levels | regulation of B cell activation | regulation of cellular localization | intracellular signal transduction | enzyme activator activity | regulation of localization | regulation of cell cycle G1/S phase transition | protein kinase regulator activity | regulation of programmed cell death | response to X-ray | regulation of immune system process | response to hormone | negative regulation of cellular process | negative regulation of kinase activity | cellular response to UV-B | positive regulation of lymphocyte activation | regulation of protein import | cell differentiation | positive regulation of fibroblast proliferation | protein serine/threonine kinase inhibitor activity | intrinsic apoptotic signaling pathway in response to DNA damage | cellular response to extracellular stimulus | response to drug | negative regulation of protein phosphorylation | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | regulation of G1/S transition of mitotic cell cycle | positive regulation of phosphate metabolic process | cellular process | cell maturation | mitotic DNA integrity checkpoint | negative regulation of G1/S transition of mitotic cell cycle | kinase regulator activity | positive regulation of reactive oxygen species metabolic process | protein kinase inhibitor activity | positive regulation of protein kinase activity | negative regulation of apoptotic process | cellular response to starvation | response to corticosterone | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | intrinsic apoptotic signaling pathway | regeneration | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cyclin-dependent protein kinase activity | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | epithelium development | signal transduction involved in mitotic DNA damage checkpoint | response to UV | response to stimulus | enzyme inhibitor activity | cyclin-dependent protein kinase activity | regulation of cellular protein localization | regulation of mitotic cell cycle phase transition | positive regulation of immune system process | positive regulation of protein metabolic process | cellular response to light stimulus | response to stress | negative regulation of protein kinase activity | positive regulation of lymphocyte proliferation | regulation of cell proliferation | regulation of cell cycle phase transition | positive regulation of B cell proliferation | epithelial cell development | response to starvation | protein serine/threonine kinase activity | programmed cell death | positive regulation of cell activation | response to alcohol | response to temperature stimulus | cell cycle G1/S phase transition | regulation of protein transport | negative regulation of metabolic process | protein modification process | intestinal epithelial cell development | regulation of peptide transport | macromolecule modification | activation of protein kinase activity | regulation of intracellular transport | molecular function regulator | response to nitrogen compound | apoptotic process | response to light stimulus | positive regulation of mononuclear cell proliferation | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | negative regulation of mitotic cell cycle phase transition | DNA damage response, signal transduction by p53 class mediator | negative regulation of growth | negative regulation of phosphate metabolic process | mitotic DNA damage checkpoint | multicellular organism development | negative regulation of catalytic activity | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | cellular response to amino acid starvation | DNA damage response, signal transduction resulting in transcription | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | response to ketone | cellular response to stress | response to lipid | cell cycle | negative regulation of cyclin-dependent protein serine/threonine kinase activity | cellular response to heat | response to UV-B | regulation of protein import into nucleus, translocation | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular response to radiation | negative regulation of smooth muscle cell proliferation | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | negative regulation of protein serine/threonine kinase activity | response to corticosteroid | cellular response to gamma radiation | regulation of cellular protein metabolic process | G2/M transition of mitotic cell cycle | response to hyperoxia | phosphorylation | digestive tract development | response to toxic substance | signal transduction involved in cell cycle checkpoint | mitotic cell cycle phase transition | protein phosphorylation | response to gamma radiation | phosphate-containing compound metabolic process | cellular response to UV | mitotic G1 DNA damage checkpoint | cyclin-dependent protein kinase activating kinase activity | epithelial cell maturation | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | cell cycle G2/M phase transition | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | regulation of protein phosphorylation | negative regulation of vascular smooth muscle cell proliferation | positive regulation of B cell activation | intestinal epithelial cell differentiation | negative regulation of cell growth | apoptotic signaling pathway | cell aging | regulation of mitotic cell cycle | positive regulation of molecular function | regulation of nucleocytoplasmic transport | positive regulation of cell cycle arrest | negative regulation of cyclin-dependent protein kinase activity | protein metabolic process | regulation of fibroblast proliferation | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | G1 DNA damage checkpoint | regulation of protein import into nucleus | digestive system development | cell cycle arrest | kinase inhibitor activity | regulation of kinase activity | cyclin-dependent protein serine/threonine kinase activity | replicative senescence | anatomical structure development | kinase activator activity | mitotic cell cycle | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | metabolic process | response to mineralocorticoid | positive regulation of leukocyte activation | developmental maturation | negative regulation of programmed cell death | negative regulation of mitotic cell cycle | positive regulation of cell death | protein kinase activity | organic substance metabolic process | cell death | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of programmed cell death | signal transduction involved in mitotic cell cycle checkpoint | positive regulation of kinase activity | response to heat | cellular response to ionizing radiation | regulation of phosphate metabolic process | intrinsic apoptotic signaling pathway by p53 class mediator | negative regulation of cell cycle | negative regulation of protein metabolic process | negative regulation of cell cycle G1/S phase transition | negative regulation of molecular function | cellular senescence | response to arsenic-containing substance | signaling | mitotic cell cycle arrest | response to organic cyclic compound | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | cell development | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | signal transduction involved in DNA damage checkpoint | kinase activity | developmental process | regulation of DNA biosynthetic process | cyclin-dependent protein serine/threonine kinase inhibitor activity | positive regulation of cell cycle process | regulation of cell growth | cellular protein modification process | mitotic G1/S transition checkpoint | columnar/cuboidal epithelial cell development | tube development | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of B cell proliferation | negative regulation of cell proliferation | Ras protein signal transduction | response to organonitrogen compound | cell cycle phase transition | epithelial cell differentiation | response to amino acid starvation | signal transduction involved in mitotic G1 DNA damage checkpoint | intestinal epithelial cell maturation | positive regulation of metabolic process | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of protein localization | regulation of cell death | regulation of smooth muscle cell proliferation | response to steroid hormone | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | negative regulation of cell death | aging | regulation of cellular component organization | response to ionizing radiation | signal transduction | animal organ regeneration | response to glucocorticoid | cyclin-dependent protein serine/threonine kinase regulator activity | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | protein kinase complex | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | nucleoplasm | transferase complex | perinuclear region of cytoplasm | serine/threonine protein kinase complex | membrane-bounded organelle | nucleus | organelle | PCNA-p21 complex | membrane-enclosed lumen | cyclin-dependent protein kinase holoenzyme complex | cytosol | intracellular
