QuickView for DFFB;jsessionid=61AC5CDF560B638E903ADE510E6003D2;jsessionid=9CCE06785B0F273B36716F467EFEFDA0;jsessionid=036659CC36B2EA7706D5C5BA39EDF395 (gene)
- Gene Symbol:
- Dffb
Rattus norvegicus - Full name:
- DNA fragmentation factor subunit beta
- Synonyms:
- Cad, DNA fragmentation factor subunit beta, DFF-40, DNA fragmentation factor 40 kDa subunit, DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase), DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase), DNA fragmentation factor, beta polypeptide (caspase-activated DNase), DNA fragmentation factor, beta subunit, caspase-activated DNase, caspase-activated deoxyribonuclease
- Genomic Location:
- Chr 5: 170750718-170762034
- Description:
-
endogenous endonuclease; mediates caspase-3-dependent internucleosomal DNA degradation and related nuclear alterations
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
nuclease activity | enzyme binding | nucleic acid binding | disordered domain specific binding | hydrolase activity | catalytic activity | protein domain specific binding | deoxyribonuclease activity | DNA binding | hydrolase activity, acting on ester bonds | identical protein binding | organic cyclic compound binding | protein binding | heterocyclic compound binding
GO Biological Process
brain development | protein homooligomerization | nuclease activity | nervous system development | cellular process | organic substance catabolic process | DNA catabolic process, endonucleolytic | apoptotic nuclear changes | apoptotic DNA fragmentation | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | head development | execution phase of apoptosis | programmed cell death | cellular component disassembly involved in execution phase of apoptosis | cellular nitrogen compound metabolic process | nucleic acid phosphodiester bond hydrolysis | cellular component assembly | nucleobase-containing compound catabolic process | apoptotic process | system development | nitrogen compound metabolic process | multicellular organism development | protein complex oligomerization | apoptotic chromosome condensation | chromosome condensation | deoxyribonuclease activity | aromatic compound catabolic process | protein-containing complex assembly | DNA metabolic process | cellular macromolecule catabolic process | anatomical structure development | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | animal organ development | DNA packaging | DNA catabolic process | developmental process | organelle organization | DNA conformation change | heterocycle metabolic process | central nervous system development | chromosome organization | cellular metabolic process | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular
