QuickView for Ets-1;jsessionid=406D2DB3506D76AC78317CA48EFD2D27;jsessionid=87EB4112F8D857BD0813791FA66B1DC4;jsessionid=AF3F02DB70D9822C5AEDE1BD860D277E;jsessionid=7A527B91856583F1075A4F6741ADEADB (gene)

Gene Symbol:

ETS1 Homo sapiens

Full name:

ETS proto-oncogene 1, transcription factor

Synonyms:

ETS-1, EWSR2, c-ets-1, p54, protein C-ets-1, Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1, v-ets avian erythroblastosis virus E2 oncogene homolog 1, v-ets avian erythroblastosis virus E26 oncogene homolog 1

Genomic Location:

Chr 11: 127833870-127897371

Description:

This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development...

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This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CTTGTAT_MIR381 ,  RTAAACA_FREAC2_01 ,  ACTGTAG_MIR139 ,  STAT4_01 ,  PR_02 ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  PR_01 ,  YTATTTTNR_MEF2_02 ,  CATTGTYY_SOX9_B1 ,  TGTGTGA_MIR377 ,  TTTGTAG_MIR520D ,  GGCACAT_MIR455 ,  CTTTGA_LEF1_Q2 ,  TTTNNANAGCYR_UNKNOWN ,  GR_Q6_01 ,  GGGCATT_MIR365 ,  AGCATTA_MIR155 ,  TTGGAGA_MIR5155P_MIR519E ,  ACATTCC_MIR1_MIR206 ,  ATGCTGG_MIR338 ,  CAGNYGKNAAA_UNKNOWN ,  CTCAGGG_MIR125B_MIR125A ,  NKX62_Q2 ,  TGCCTTA_MIR124A ,  GTTTGTT_MIR495 ,  GCAAAAA_MIR129 ,  ACTGCCT_MIR34B ,  MEIS1_01 ,  ATACTGT_MIR144 ,  GFI1_01 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  GATA4_Q3 ,  IK2_01 ,  STAT5A_04 ,  GTTATAT_MIR410 ,  CAGCTG_AP4_Q5 ,  CGTCTTA_MIR208 ,  CACTTTG_MIR520G_MIR520H ,  ACACTGG_MIR199A_MIR199B ,  ATGTAGC_MIR221_MIR222

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-208 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-455 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-499 ,  Predicted Gene Targets for miR-505 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

11q24.3

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